For this reason method’s relatively insensitive nature, in addition, it will take at least a couple of years to identify progression of damage that is captured on radiographs. Recently, experts in the Netherlands recognized a novel marker linked to both the prevalence and the progression of OA, at the knee and the hip particularly. In the August 2004 problem of Arthritis & Rheumatism They talk about their breakthrough findings. Building on the analysis of cartilage metabolism, the experts concentrated on peptide fragments of type II collagen.In statistical conditions, the probability that the random adjustable Z could have a value higher than 4.0 is expressed as Pr, which equals 3 in 100 approximately,000. This approach implicitly assumes that each woman carries the same proportion of genetic material on a given chromosome. In fact, chromosomes vary slightly in size and composition from individual to individual due to inherited or de novo copy-number variants, when a genomic region is certainly deleted or duplicated.