Hibberd, Ph.D., Sen Yang, M.D., Ph.D., Xue-Jun Zhang, M.D., Ph.D., and Jian-Jun Liu, Ph.D.: Genomewide Association Research of Leprosy Leprosy is a chronic infectious disease caused by Mycobacterium leprae. It impacts the skin and peripheral nerves and will cause irreversible impairment of nerve function and consequent chronic disabilities.1 Despite a dramatic reduction in its prevalence in the last two decades ,2 leprosy remains a major public health issue and one of the most important preventable disabilities in many developing countries.3 Hence, it is particularly unfortunate that study into the mechanisms underlying infection and medical sequelae has been tied to the fact that M. Leprae infects just humans and can’t be cultured in vitro.4 The clinical disease of leprosy evolves in a minority of infected persons,5 and it manifests as a spectrum of disease symptoms that derive from interactions between the host’s immune response and the bacterium.He couldn’t sit down, the legs were so swollen, she explained. She brings him morphine. Before the morphine, Patrick wasn’t able to walk – he previously to be brought in a wheelchair. So after, like, two weeks of morphine he started walking, said Birungi. That may audio unremarkable, however in Uganda and many other countries it’s nothing short of a miracle. The known truth can be, 80 % of the world’s inhabitants lives in countries with little if any access to morphine. That’s roughly 5 billion people making do with simply 5 % of the global supply.