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The secondary end factors were the duration of delayed graft function, major nonfunction , the particular area beneath the curve of the daily serum creatinine level at times 1 to 14, the creatinine clearance at time 14, biopsy-proven acute rejection, toxicity of the calcineurin inhibitor, the length of the recipient’s medical center stay, and survival of the graft and affected person up to 1 1 year after transplantation. Data on graft survival were censored at the right time of loss of life in patients who have died with a functioning allograft. In addition to the primary end stage, which was defined in terms of the requirement for dialysis after transplantation, we also examined delayed graft function as a secondary end point. This secondary end stage, useful delayed graft function, was defined when it comes to the lack of a decrease in the serum creatinine level of at least 10 percent per day for at least 3 consecutive times in the initial week after transplantation, excluding patients in whom acute rejection, toxicity of the calcineurin inhibitor, or both developed within the initial week.15 All end points described above were prespecified in the analysis protocol, except primary nonfunction, which was added post hoc.