The reduction in LDL cholesterol seen in this analysis is related to that seen in individuals taking ezetimibe so hopes are high. Can teach us about the underlying causes of disease and indicate important drug targets.. An individual gene mutation can halve the risk of heart disease By Kate Bass BSc Latest research shows that inactivation of a single gene reduces the chance of coronary attack by 50 percent. It is widely known that lowering bloodstream LDL cholesterol can reduce the risk of cardiovascular disease. The prescribed statins avoid the body from producing cholesterol widely. In contrast, the drug ezetimibe helps prevent dietary cholesterol from being absorbed into the bloodstream.Hazard ratios indicating the consequences of prognostic elements on the risk of death were calculated and are proven in a forest plot.23 The interaction test was used to assess the heterogeneity of treatment results for subgroup analyses.24 Evaluation of the QLQ-C30 questionnaires was performed in accordance with the EORTC guidelines.25 The preplanned analysis devoted to the scales that are usually most affected in patients with pancreatic cancer: the Global Health Status and Quality of Life level and scales for fatigue, pain, physical functioning, psychological functioning, and role functioning.26 The other QLQ-C30 domains were only examined within an exploratory manner.